Rubio: Reports of immigration deal 'premature'

WASHINGTON (AP) ? Even with one of the largest hurdles to an immigration overhaul overcome, optimistic lawmakers on Sunday cautioned they had not finished work on a bill that would provide a path to citizenship for 11 million illegal immigrants.

The AFL-CIO and the pro-business U.S. Chamber of Commerce reached a deal late Friday that would allow tens of thousands of low-skill workers into the country to fill jobs in construction, restaurants and hotels. Yet despite the unusual agreement between the two powerful lobbying groups, lawmakers from both parties conceded that the negotiations were not finished.

"With the agreement between business and labor, every major policy issue has been resolved," said Sen. Chuck Schumer, the New York Democrat who brokered the labor-business deal.

But it hasn't taken the form of a bill and the eight senators searching for a compromise haven't met about the potential breakthrough.

"We haven't signed off," said Sen. Lindsey Graham, R-S.C.

"There are a few details yet. But conceptually, we have an agreement between business and labor, between ourselves that has to be drafted," he added.

Yet just before lawmakers began appearing on Sunday shows, Sen. Marco Rubio warned he was not ready to lend his name ? and political clout ? to such a deal without hashing out the details.

"Reports that the bipartisan group of eight senators have agreed on a legislative proposal are premature," said Rubio, a Florida Republican who is among the lawmakers working on legislation.

Rubio, a Cuban-American who is weighing a presidential bid in 2016, is a leading figure inside his party. Lawmakers will be closely watching any deal for his approval and his skepticism about the process did little to encourage optimism.

Rubio, who is the group's emissary to conservatives, called the agreement "a starting point" but said 92 senators from 43 states haven't yet been involved in the process.

The detente between the nation's leading labor federation and the powerful business lobbying group still needs senators' approval, including a nod from Sen. John McCain, the Arizona Republican whose previous efforts came up short.

"I think we're on track. . But as Sen. Rubio correctly says, we have said we will not come to final agreement till we look at all of the legislative language and he's correctly pointing out that that language hasn't been fully drafted," Schumer said.

Sen. Jeff Flake, R-Ariz., also noted the significance of the truce between labor and business but added that this wasn't yet complete.

"That doesn't mean we've crossed every 'i' or dotted every 't,' or vice versa," said Flake, who is among the eight lawmakers working on the deal.

Schumer negotiated the deal between AFL-CIO president Richard Trumka and Chamber of Commerce head Tom Donohue during a late-Friday phone call. Under the compromise, the government would create a new "W'' visa for low-skill workers who would earn wages paid to Americans or the prevailing wages for the industry they're working in, whichever is higher. The Labor Department would determine prevailing wage based on customary rates in specific localities, so that it would vary from city to city.

The proposed measure would secure the border, crack down on employers, improve legal immigration and create a 13-year pathway to citizenship for the millions of illegal immigrants already here.

It's a major second-term priority of President Barack Obama's and would usher in the most dramatic changes to the faltering U.S. immigration system in more than two decades.

"This is a legacy item for him. There is no doubt in my mind that he wants to pass comprehensive immigration reform," said David Axelrod, a longtime political confidant of Obama.

During the last week, an immigration deal seemed doomed. But the breakthrough late Friday restarted the talks.

Ultimately the new "W'' visa program would be capped at 200,000 workers a year, but the number of visas would fluctuate, depending on unemployment rates, job openings, employer demand and data collected by a new federal bureau being pushed by labor groups as an objective monitor of the market, according to an official involved with the talks who also spoke on condition of anonymity ahead of a formal announcement.

A "safety valve" would allow employers to exceed the cap, the official said, if they could show need and pay premium wages, but any additional workers brought in would be subtracted from the next year's cap.

The workers could move from employer to employer and would be able to petition for permanent residency and ultimately seek U.S. citizenship. Neither is possible for temporary workers now.

"As to the 11 million (illegal immigrants), they'll have a pathway to citizenship, but it will be earned, it will be long, and it will be hard, and I think it is fair," Graham said.

The new program would fill needs employers say they have that are not currently met by U.S. immigration programs. Most industries don't have a good way to hire a steady supply of foreign workers because there's one temporary visa program for low-wage nonagricultural workers but it's capped at 66,000 visas per year and is only supposed to be used for seasonal or temporary jobs.

Separately, the new immigration bill also is expected to offer many more visas for high-tech workers, new visas for agriculture workers, and provisions allowing some agriculture workers already in the U.S. a speedier path to citizenship than that provided to other illegal immigrants, in an effort to create a stable agricultural workforce.

Schumer, Flake and Axelrod appeared on NBC's "Meet the Press." Graham was interviewed on CNN's "State of the Union."

___

Associated Press writer Erica Werner contributed to this report.

Source: http://news.yahoo.com/rubio-reports-immigration-deal-premature-144123665--politics.html

Oscar Results Jennifer Lawrence Fall Ang Lee les miserables jennifer lawrence Oscar Winners 2013 quentin tarantino

Jim Carrey Fights Back Against Fox News Vitriol

Source: http://www.thehollywoodgossip.com/2013/03/jim-carrey-fights-back-against-fox-news-vitriol/

ncaa bracket bracket Jason Terry Steubenville rape Beyonce Bow Down Jason Molina UCF

Keep Drinks Upright with a Roll of Tape

If you find yourself in a situation where your drink might get bumped, sticking it inside a big roll of tape can keep it from spilling.

This trick could come in handy at a party where someone might knock it over, but it has its uses in everyday life as well. I might use this at my computer desk or when playing video games so my drink won't get upended by any wires, and it could also save you from a big headache at your workbench, where an erratic swing of a hammer could send it flying.

My Drink Anti-Tipping Device | Reddit

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/W1uzodpvz3Y/use-a-roll-of-tape-to-keep-your-drink-upright

ivan rodriguez planetary resources mothers day gift ideas natalee holloway scotty mccreery megan fox pregnant metta world peace suspension

Maria Shriver No Makeup: 57-Year-Old Sports Swimsuit, Goes Au Naturel In Hawaii (PHOTOS)

Maria Shriver looked flawless as she went makeup-free while vacationing in Hawaii with her family on March 29.

Joined by her kids Katherine and Patrick Schwarzenegger and Patrick's girlfriend Taylor Burns, Shriver was seen building a sand castle before taking a walk along the water's edge, sporting a black zip-up swimsuit and sheer cover up.

The 57-year-old appeared happier than ever following her divorce from her husband of 25 years, Arnold Schwarzenegger, after his admission he fathered a child with the family housekeeper in 2011.

Check out Maria with no makeup below:

Also on HuffPost:

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2013/03/30/maria-shriver-no-makeup-photos_n_2985046.html

post grad arpaio carol burnett neil degrasse tyson neil degrasse tyson davy jones death born this way foundation

Third Eye Crime - a unique mix of pathfinding gameplay and film noire

?

Third Eye Crime is a promising puzzle game for iOS that we got to spend some time playing at GDC 2013. Players have to guide a thief through a maze filled with security guards without getting caught. Sounds simple, right? Wait until you see how many guards there are later on in the game and how big their guns are. Luckily, your character can read minds, so you can see where guards have visibility, and around which corners they think you are. To keep things interesting, each level has a comic book style interstitial which tells the game's chilling tale of intrigue.

?

Though the premise of a psychic art burglar in a film noir graphic novel setting is a little out there, the developer explained that it really came from a common artificial intelligence mechanic. Basically, when you play any game with AI opponents, these visibility cones and pathfinding maps already exist in some capacity, except they're typically hidden in the background. By explicitly showing these regions, levels can be made much more difficult, and some might say interesting.

I'm pretty excited to try out Third Eye Crime when it comes out in early June. 80 - 90 levels should be plenty to chew on for awhile. ?What do you guys think?

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/5OF6gEDuSyw/story01.htm

lightsquared david lee honduras prison fire do not call list sports illustrated westminster dog show 2012 words with friends

Satechi 10-Port USB 3.0 Hub

By Ahmer Kazi Who can argue with having more USB ports? This question rings especially true in an age where folks typically have more USB-enabled devices than available USB ports on our PCs. The Satechi 10-Port USB 3.0 Hub ($69.99 list) aims to address this imbalance by serving up a hub that adds a net gain of nine additional USB 3.0 ports and can charge tablet devices like the Apple iPad. Although it's somewhat pricey and requires an external power supply, it nonetheless succeeds in multiplying your connectivity options more than any of the ports that we've seen thus far. If you have a bunch of peripherals or are simply tired of constantly swapping devices in your system's USB ports, it's worth checking out.

The 10-Port USB 3.0 Hub's plastic chassis measures 1.06 by 1.75 by 8.69 inches (HWD), resulting in a long thin strip that looks a lot like a surge protector. While its glossy black finish is easy on the eyes and complements its array of blue USB 3.0 ports and LED lights, it also attracts a considerable amount of smudges and fingerprints much like the Satechi Slim Surge Protector. Although, the 10-Port USB 3.0 Hub itself is slim enough to slip into your laptop bag or place on your desk without occupying too much space, its power supply adds some bulk.

As its name suggests, there's a total of ten USB 3.0 ports on the 10-Port USB 3.0 Hub. It connects to your system via the included USB 3.0 cable, and the net gain of nine USB 3.0 ports yields far more connectivity options than either the Satechi Ultra Portable 4 Port USB Pocket Hub or the Targus Ultralife USB Hub with Ethernet Port.

Nine of the 10-Port USB 3.0 Hub's USB 3.0 ports are housed on the face of the hub. These nine ports are divided into groups of three, and three corresponding switches on the front panel's left side control the power supply for each group. When switched on, a blue LED accordingly illuminates the corresponding trio of ports. Thanks to the 10-Port USB 3.0 Hub's strip-shape design, there's enough space to prevent neighboring ports from overcrowding one another. The 10-Port USB 3.0 Hub's tenth and final USB port, meanwhile, sits alone on the right panel alongside its own dedicated on/off switch. Unlike the 0.9 amp of power found in the other nine ports, this particular port provides 2.1 amps, and its increased amperage allows it to charge iPads and other similarly-sized tablets.

During testing, the 10-Port USB 3.0 Hub worked just as one would expect, and I experienced no difference in performance when transferring a 1.22GB test folder from a flash drive plugged directly into my computer and when it was plugged into the 10-Port USB 3.0 Hub. The 10-Port USB 3.0 Hub is compatible with Windows (98SE/ME/2000/XP/Vista/7/8) and Mac (OS 9.1 or later), and since it's a plug-and-play device, setting it up requires little beyond plugging it into one of your system's USB ports and a power outlet. Like the Satechi 3.0 4-Port USB Hub, it relies on an external power source. While I typically prefer bus-powered hubs for their unfettered portability, this shortcoming is more forgivable in the case of the 10-Port USB 3.0 Hub since it requires more electric current stability for its considerable amount of ports and tablet-charging capability.

All said, the Satechi 10-Port USB 3.0 Hub is an efficient way to multiply your USB 3.0 connectivity options. Although it costs a bit more than the competitors and requires an external power supply, these shortcomings are understandable considering its net gain of nine USB 3.0 ports and compact size. If you find yourself juggling a bunch of peripherals or have simply grown tired of constantly swapping peripherals out of your USB ports, it's worth checking out.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/DdZT60s8qOY/0,2817,2417216,00.asp

ncaa bracket 2012 kyle orton kyle orton 2012 ncaa bracket john carlson greg smith catamount

Samsung Exynos Octa now rocking LTE, destined for Korean market

When Samsung's Exynos 5 Octa was announced, it was believed to be compatible with 3G networks only. As such, the HSPA+ (global) version of the Galaxy S 4 was the only handset to feature the company's eight-core SoC -- the LTE model shipping with Qualcomm's 4G-capable, quad-core Snapdragon 600 instead. That's apparently changed, with the Korean giant tweeting that the Exynos 5 Octa now supports LTE on 20 bands. So why even make a Snapdragon 600 version of the Galaxy S 4, then? Perhaps Samsung can't produce as many chips as Qualcomm to meet the upcoming worldwide demand for its new flagship. This appears likely, with inews24 and new-samsunggalaxys4 reporting that the Exynos 5 Octa with LTE is currently reserved for Korean models only (SHV-E300S, SHV-E300K and SHV-E300L, to be exact). So, anyone fancy a trip to Seoul in the near future?

Filed under: Cellphones, Mobile, Samsung

Comments

Via: GSMArena

Source: SamsungExynos (Twitter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/AQM-acFnr4A/

Zero Dark Thirty Academy Awards 2013 Django Unchained jennifer hudson jennifer garner jennifer garner daytona 500

Unlike AT&T, Verizon reportedly putting promotional muscle behind BlackBerry Z10 launch

Ben Carson, the neurosurgeon-turned-conservative-pundit, has accumulated legions of right-leaning fans since he stumped at the National Prayer Breakfast in February and, later, began appearing on Fox News Channel. But after delivering widely condemned comments regarding gay people?on Fox this week, a group of students at Johns Hopkins, where Carson has worked since 1977, has successfully stopped Carson from speaking?at the May commencement ceremony?of the university's medical school. ...

Source: http://news.yahoo.com/unlike-t-verizon-reportedly-putting-promotional-muscle-behind-142056565.html

bruce weber boston globe google maps 8 bit mirror mirror robyn texas relays meniscus

Syracuse Final Four Berth Secured With 55-39 Win Over Marquette In Elite Eight (PHOTOS)

Fred Van Vleet, Aaron Craft

Wichita State's Fred Van Vleet, left, and Ohio State guard Aaron Craft chase a loose ball during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

LaQuinton Ross

Ohio State forward LaQuinton Ross pauses during the second half of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Wichita State players react from the bench during the second half against Ohio State in the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Cleanthony Early

Wichita State's Cleanthony Early, right, is examined after suffering an injury during the second half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Wichita State players sits on the bench during the second half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Fred Van Vleet, Aaron Craft

Ohio State guard Aaron Craft, top, and Wichita State guard Fred Van Vleet scramble for a loose ball during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Sam Thompson, Carl Hall

Ohio State forward Sam Thompson drives against Wichita State forward Carl Hall during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Deshaun Thomas, Carl Hall

Ohio State forward Deshaun Thomas, left, and Wichita State forward Carl Hall get tangled up during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Wichita State players react to a field goal scored against Ohio State during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Aaron Craft, Malcolm Armstead

Wichita State guard Malcolm Armstead, right, works against Ohio State guard Aaron Craft (4) during the second half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Carl Hall, Deshaun Thomas

Wichita State forward Carl Hall, left, shoots against Ohio State's Deshaun Thomas (1) and another defender during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Carl Hall, Amir Williams, Deshaun Thomas

Wichita State forward Carl Hall, left, has a shot rejected by Ohio State's Ohio State's Amir Williams (23) as Ohio State's Deshaun Thomas (1) helps defend during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

The Ohio State cheer team performs during the first half of the West Regional final between Ohio State and Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Thad Matta

Ohio State head coach Thad Matta argues a call during the first half of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Thad Matta

Ohio State coach Thad Matta calls to his players during the first half of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Thad Matta

Ohio State coach Thad Matta reacts during the first half of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Gregg Marshall

Wichita State coach Gregg Marshall talks to his players during the first half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Gregg Marshall, Cleanthony Early

Wichita State coach Gregg Marshall talks to Cleanthony Early during the first half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Gregg Marshall

Wichita State coach Gregg Marshall talks to his players during the first half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Carl Hall, Amir Williams, Deshaun Thomas

Wichita State forward Carl Hall (22) has a shot rejected by Ohio State center Amir Williams (23) as Ohio State forward Deshaun Thomas helps on defends during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Carl Hall

Wichita State forward Carl Hall celebrates a field goal against Ohio State during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Demetric Williams, Cleanthony Early

Wichita State guard Demetric Williams (5) celebrates a 3-pointer against Ohio State with teammate Cleanthony Early (11) during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Amir Williams, Carl Hall, Aaron Craft, Shannon Scott

Wichita State forward Carl Hall, rear, and Ohio State guards Aaron Craft, center, and Shannon Scott, right, scramble for a loose ball during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. Ohio State center Amir Williams is at left. (AP Photo/Jae C. Hong)

Cleanthony Early, Aaron Craft

Wichita State forward Cleanthony Early (11) and Ohio State guard Aaron Craft (4) compete for a loose ball during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

John Legend, Chrissy Teigen

John Legend, right, is joined by model Chrissy Teigen during the first half of the West Regional final between Wichita State and Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Deshaun Thomas, Carl Hall

Ohio State forward Deshaun Thomas, left, and Wichita State forward Carl Hall vie for possession of the ball during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

LaQuinton Ross, Chadrack Lufile

Ohio State forward LaQuinton Ross, left, tries to shoot against Wichita State forward Chadrack Lufile under the basket during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Cleanthony Early, LaQuinton Ross

Wichita State forward Cleanthony Early (11) tries for a basket over Ohio State forward LaQuinton Ross (10) during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Malcolm Armstead, Deshaun Thomas

Wichita State guard Malcolm Armstead (2) looks over Ohio State defender Ohio State's Deshaun Thomas during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Ehimen Orukpe, Deshaun Thomas

Wichita State center Ehimen Orukpe (21) goes up against Ohio State forward Deshaun Thomas (1) during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Thad Matta

Ohio State coach Thad Matta watches during the first half of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Evan Ravenel, Carl Hall

Ohio State forward Evan Ravenel (30) drives against Wichita State forward Carl Hall (22) during the first half of the West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Gregg Marshall

Wichita State coach Gregg Marshall argues a call with a referee during the first half of the West Regional final against Ohio State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Ehimen Orukpe, Deshaun Thomas

Wichita State center Ehimen Orukpe, left, defends as Ohio State forward Deshaun Thomas takes aim during the first half of a West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Syracuse players and coaches celebrate for photographers after their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Rakeem Christmas

Syracuse forward Rakeem Christmas (25) high-fives fans while leaving the court after their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Deshaun Thomas, Cleanthony Early

Ohio State forward Deshaun Thomas (1) tries to work around Wichita State forward Cleanthony Early during the first half of a West Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Davante Gardner

Marquette forward Davante Gardner (54) sits on the bench during the second half of the East Regional final in the NCAA men's college basketball tournament against Syracuse, Saturday, March 30, 2013, in Washington. Syracuse won 55-39. (AP Photo/Alex Brandon)

Ohio State players gather in an arena tunnel shortly before tip-off of the West Regional final against Wichita State in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Los Angeles. (AP Photo/Jae C. Hong)

Michael Carter-Williams

Syracuse guard Michael Carter-Williams holds up the trophy following their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Michael Carter-Williams

Syracuse guard Michael Carter-Williams (1) celebrates after cutting down the net following their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

C.J. Fair

Syracuse forward C.J. Fair (5) cuts down the net following their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Syracuse head coach Jim Boeheim cuts down the net following their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Syracuse guard Michael Carter-Williams celebrates after their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Syracuse forward C.J. Fair (5) smiles as he walks off the court after their 55-39 win over Marquette in the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Michael Carter-Williams, C.J. Fair

Syracuse guard Michael Carter-Williams (1) hugs forward C.J. Fair (5) after their 55-39 win over Marquette in the East Regional final of the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

Davante Gardner

Marquette forward Davante Gardner (54), guard Vander Blue (13) and forward Jamil Wilson (0) walk off the court after their 55-39 loss to Syracuse in the East Regional final of the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Alex Brandon)

C.J. Fair, Junior Cadougan

Syracuse forward C.J. Fair (5) falls on Marquette guard Junior Cadougan (5) during the first half of the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

James Southerland, Junior Cadougan, Baye Keita

Syracuse forward James Southerland (43) lands on Marquette guard Junior Cadougan (5) as Syracuse center Baye Keita (12) looks for the rebound during the second half of the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Pablo Martinez Monsivais)

C.J. Fair, Jamil Wilson

Syracuse forward C.J. Fair (5) shoots over Marquette forward Jamil Wilson (0) during the second half of the East Regional final in the NCAA men's college basketball tournament, Saturday, March 30, 2013, in Washington. (AP Photo/Alex Brandon)

Barack Obama

President Barack Obama sits with NCAA President Mark Emmert, top, as they attend the East Regional final of the NCAA men's college basketball tournament between Syracuse and Marquette, Saturday, March 30, 2013, in Washington. (AP Photo/Carolyn Kaster)

Source: http://www.huffingtonpost.com/2013/03/30/syracuse-marquette-ncaa-elite-eight_n_2985970.html

proposition 8 ricky martin chauncey billups caucus results exton ricky williams kurt warner

New metabolite-based diagnostic test could help detect pancreatic cancer early

Public release date: 29-Mar-2013
[ | E-mail | Share ]

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7155
American Association for Cancer Research

PHILADELPHIA A new diagnostic test that uses a scientific technique known as metabolomic analysis may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection.

Researchers examined the utility of metabolomic analysis as a diagnostic method for pancreatic cancer and then validated the new approach, according to study results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Although surgical resection can be a curative treatment for pancreatic cancer, more than 80 percent of patients with pancreatic cancer have a locally advanced or metastatic tumor that is unresectable at the time of detection," said Masaru Yoshida, M.D., Ph.D., associate professor and chief of the Division of Metabolomics Research at Kobe University Graduate School of Medicine in Kobe, Japan. "Conventional examinations using blood, imaging and endoscopy are not appropriate for pancreatic cancer screening and early detection, so a novel screening and diagnostic method for pancreatic cancer is urgently required."

Using gas chromatography mass spectrometry, the researchers measured the levels of metabolites in the blood of patients with pancreatic cancer, patients with chronic pancreatitis and healthy volunteers. They randomly assigned 43 patients with pancreatic cancer and 42 healthy volunteers to a training set and 42 patients with pancreatic cancer and 41 healthy volunteers to a validation set. They included all 23 patients with chronic pancreatitis in the validation set.

Analysis of the metabolomic data generated from the training set indicated that levels of 18 metabolites were significantly different in the blood of patients with pancreatic cancer compared with the healthy volunteers. Further investigation led the researchers to develop a method to predict a pancreatic cancer diagnosis using assessment of the levels of just four metabolites. In the training set, the approach demonstrated 86 percent sensitivity and 88.1 percent specificity. When tested again in the validation set, which included patients with chronic pancreatitis, the method demonstrated 71.4 percent sensitivity and 78.1 percent specificity.

"Our diagnostic approach using serum metabolomics possessed higher accuracy than conventional tumor markers, especially at detecting the patients with pancreatic cancer in the cohort that included the patients with chronic pancreatitis," Yoshida said. "This novel diagnostic approach, which is safe and easy to apply as a screening method, is expected to improve the prognosis of patients with pancreatic cancer by detecting their cancers early, when still in a resectable and curable state."

###

Follow the AACR on Twitter: @aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the American Association for Cancer Research

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit http://www.AACR.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 29-Mar-2013
[ | E-mail | Share ]

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7155
American Association for Cancer Research

PHILADELPHIA A new diagnostic test that uses a scientific technique known as metabolomic analysis may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection.

Researchers examined the utility of metabolomic analysis as a diagnostic method for pancreatic cancer and then validated the new approach, according to study results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Although surgical resection can be a curative treatment for pancreatic cancer, more than 80 percent of patients with pancreatic cancer have a locally advanced or metastatic tumor that is unresectable at the time of detection," said Masaru Yoshida, M.D., Ph.D., associate professor and chief of the Division of Metabolomics Research at Kobe University Graduate School of Medicine in Kobe, Japan. "Conventional examinations using blood, imaging and endoscopy are not appropriate for pancreatic cancer screening and early detection, so a novel screening and diagnostic method for pancreatic cancer is urgently required."

Using gas chromatography mass spectrometry, the researchers measured the levels of metabolites in the blood of patients with pancreatic cancer, patients with chronic pancreatitis and healthy volunteers. They randomly assigned 43 patients with pancreatic cancer and 42 healthy volunteers to a training set and 42 patients with pancreatic cancer and 41 healthy volunteers to a validation set. They included all 23 patients with chronic pancreatitis in the validation set.

Analysis of the metabolomic data generated from the training set indicated that levels of 18 metabolites were significantly different in the blood of patients with pancreatic cancer compared with the healthy volunteers. Further investigation led the researchers to develop a method to predict a pancreatic cancer diagnosis using assessment of the levels of just four metabolites. In the training set, the approach demonstrated 86 percent sensitivity and 88.1 percent specificity. When tested again in the validation set, which included patients with chronic pancreatitis, the method demonstrated 71.4 percent sensitivity and 78.1 percent specificity.

"Our diagnostic approach using serum metabolomics possessed higher accuracy than conventional tumor markers, especially at detecting the patients with pancreatic cancer in the cohort that included the patients with chronic pancreatitis," Yoshida said. "This novel diagnostic approach, which is safe and easy to apply as a screening method, is expected to improve the prognosis of patients with pancreatic cancer by detecting their cancers early, when still in a resectable and curable state."

###

Follow the AACR on Twitter: @aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the American Association for Cancer Research

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit http://www.AACR.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/aafc-nmd032513.php

the colony ncaa final four 2012 uk vs louisville university of kansas buckeye west side story final four 2012

UPS to forfeit $40 million over illegal online pharmacy shipments

(Reuters) - United Parcel Service Inc has agreed to forfeit $40 million it earned from illegal Internet pharmacies shipping drugs using its services, U.S. authorities said Friday.

As part of the settlement, UPS entered a non-prosecution agreement with the U.S. Department of Justice.

The company also agreed to put a compliance program into place to prevent illegal online pharmacies from distributing drugs through its shipping services in the future, authorities said.

"Good corporate citizens like UPS play an important role in halting the flow of illegal drugs that degrade our nation's communities," Northern California U.S. Attorney Melinda Haag said in a statement.

UPS cooperated with the investigation, prosecutors said.

Prosecutors said UPS was on notice from 2003 to 2010 that Internet pharmacies were shipping drugs without prescriptions, yet the company didn't put procedures in place to shut down their accounts.

"We believe we have an obligation and responsibility to help curb the sale and shipment of drugs sold through illegal Internet pharmacies," said Susan Rosenberg, a UPS spokeswoman.

(Reporting by Nate Raymond in New York; Editing by Chizu Nomiyama)

Source: http://news.yahoo.com/ups-forfeit-40-million-over-illegal-online-pharmacy-183147419--sector.html

rupaul drag race walking dead comic kratom broncos broncos lehigh walking dead season finale

Judge: Ind. senators can't defend immigration law

INDIANAPOLIS (AP) - A federal judge on Friday rebuffed three Indiana lawmakers who asked to defend parts of the state's immigration law in court after the attorney general declined to do so.

U.S. District Judge Sarah Evans Barker, who has barred the 2011 law from taking effect until she can rule on its constitutionality, said allowing the senators to intervene would violate the state Constitution's declaration that the attorney general's office is state government's sole legal representative.

"Allowing the three individual legislators to intervene here in their official capacities as State Senators not only would conflict with this well-settled state law, but would provide the legislators a trump card with respect to the Attorney General's statutorily derived discretion in this context," Barker wrote.

Republican Senators Mike Delph, Brent Steele and Phil Boots ? who authored the immigration law ? had asked Barker to let them defend parts of the law Attorney General Greg Zoeller would not.

Zoeller's office has said it would recommend Barker strike down most of the portions of Indiana's law that would allow police to make warrantless arrests based on certain common immigration documents. The office said last year's U .S. Supreme Court decision striking down similar sections of an Arizona law rendered those parts of Indiana's law invalid. However, the office said it would defend a provision allowing for local police to arrest immigrants for whom federal authorities have issued a 48-hour detention order.

The senators, who are represented by lawyers from the Immigration Reform Law Institute in Washington, had argued the warrantless arrest provisions in Indiana's and Arizona's laws are "vastly different," and that Indiana's law is consistent with the Supreme Court's decision. They also argued they have a right to intervene as defendants because the law won't be allowed to take effect if it isn't defended, which they say effectively robs them of the votes they made in the Legislature.

"I take my responsibility to defend the statutes the Legislature passes from legal challenge as an important role of the office I hold. The court recognized that the Office of the Attorney General has faithfully defended all provisions of this statute until the U.S. Supreme Court last June said that state-level warrantless arrest laws are preempted as unconstitutional," Zoeller said in a statement Friday. "We are pleased that Judge Barker's ruling has underscored and reiterated the responsibility of my office to defend state statutes as is our solemn obligation."

The three senators did not immediately return phone calls from The Associated Press seeking comment. A Reform Law Institute spokeswoman said the attorney who represented the senators was unavailable to comment.

Source: http://www.wlfi.com/dpp/news/judge-ind-senators-cant-defend-immigration-law

kelly clarkson super bowl 2012 ok go peyton manning super bowl nsx chad ochocinco roman numerals madonna

North Carolina Eliminates Latino Outreach Office (Taegan Goddard's Political Wire)

Share With Friends: | | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/295484907?client_source=feed&format=rss

this means war bobby brown suzanne somers colbert colbert report legionnaires disease underwear bomber

Global IPOs rise on stock market rebound, private equity exits

By Olivia Oran, Kylie MacLellan and Elzio Barreto

(Reuters) - Global equity fundraising rose 24 percent in the first quarter from a year ago, as strong markets and easing concerns about the economy encouraged more companies to raise capital through initial public offerings and other capital market transactions.

Private equity-backed companies queued up to list shares as U.S. stock markets reached record highs, helping boost U.S. IPO volumes by 65 percent so far this quarter. Bankers expect more investments from the 2006-2007 buyout boom years to crowd the IPO market this year.

Investor confidence also returned after political and economic uncertainties stymied capital raising in 2012, in Europe in particular. While some risks remain, including political uncertainty in Italy stemming from an inconclusive election last month and wobbles over a bailout deal for Cyprus, stock markets have been fairly resilient in the region.

Global equity fundraising, which includes IPOs and secondary offerings, rose to $183 billion (120 billion pounds) so far this quarter from $147 billion (97 billion pounds) in the same period last year, according to Thomson Reuters data as of March 27.

IPO volumes rose 37 percent to $21 billion (13 billion pounds), as the surge in U.S. activity and a rebound in European volumes offset a 56 percent decline in Asia, the data shows.

"It's been a very active quarter as investors are rallying behind an economic recovery," said Philip Drury, co-head of equity capital markets for the Americas at Citi . "We think you are going to see a meaningful increase in the number of critical mass IPOs in the second and third quarter as market conditions are very robust, and we are advising clients to access the window of opportunity."

Private equity firms looking to sell portfolio companies are driving much of this activity in the United States across various sectors like industrials, retail and consumer, and healthcare.

Large private equity-backed companies planning IPOs later this year include eye care company Bausch & Lomb Inc, technology products retailer CDW Corp, theme park operator Sea World Parks and Entertainment and testing services company Quintiles Transnational Corp.

"Public market investors are more comfortable today with leverage on IPOs because their outlook on the business environment is more optimistic than it was in the past," said Mary Ann Deignan, head of equity capital markets for the Americas at Bank of America Merrill Lynch .

"That leads us to be able to go to financial sponsors and give them new advice about companies that we told them a year ago they couldn't take public."

U.S. technology IPOs, meanwhile, comprised a mere 8.8 percent of IPO activity, compared with 34 percent in the year prior, as fervor for the sector tempered after Facebook Inc's $16 billion (10 billion pounds) public debut in May 2012 fell flat.

In the absence of deals that hit the market in 2012, including Facebook and business software maker Workday Inc , the majority of technology offerings this year are likely to be smaller companies in sectors like business software, advertising technology and data storage, bankers say.

"There are a ton of (technology) companies out there with revenue of about $75 million (49 million pounds) to $125 million (82 million pounds) that are growing at least 20 percent a year and are profitable," said Paul Deninger, a senior managing director at Evercore Partners Inc . "Those are the deals that are going to emerge this year."

In the first quarter of this year, Goldman Sachs Group Inc topped the global ranking of equity underwriters with 86 deals accounting for proceeds of $23 billion (15 billion pounds), up from No. 2 in the first quarter of 2012. Morgan Stanley followed as No. 2 and Citigroup as No. 3.

Goldman Sachs was also the leader for global IPOs, raising $2.7 billion (1.7 billion pounds) for clients, followed by Deutsche Bank and Citigroup.

PICK-UP IN EUROPE

In Europe, improving stock markets have encouraged a string of companies to test the water for initial public offerings, which began to show signs of a pick-up in the final quarter of 2012 after years of subdued activity due to the financial crisis.

Housebuilder Crest Nicholson Holdings PLC and insurer esure Group PLC were among those going public in London, which saw the bulk of activity, while German real estate group LEG Immobilien AG completed Europe's biggest listing of the quarter when it raised 1.3 billion euros in Frankfurt.

"We've now seen a number of companies successfully getting IPOs done and other issuers ... could look to take advantage of the momentum and revisit deals that they put on the back burner," said Klaus Hessberger, co-head of EMEA ECM at JPMorgan Chase & Co .

"Investors are interested in Europe again and we're seeing U.S. money coming into European equities ... The crisis isn't over, but the market and sentiment have come a long way compared to where they were 12 months ago."

But bankers caution activity is still far from returning to normal.

"There is a reasonable pipeline but deal making activity is not at a high level. There are deals to come, but I think right now people are still looking at the market with sobriety," said Craig Coben, head of EMEA ECM at Bank of America Merrill Lynch.

In the second quarter, Dutch telecoms group KPN is expected to complete a planned 3 billion euro rights issue, while German chemical company Evonik plans to float in April.

Among others reported to be preparing to float in the coming months are Germany's biggest real estate firm, Deutsche Annington, which could yield as much as 1.5 billion euros, and Cinven-owned British insurer Partnership Assurance.

ASIA SLOWLY EMERGES

Equity issuance in Asia ex-Japan rebounded as companies took advantage of surging share prices to raise $46 billion (30 billion pounds) in stock and convertible bond offerings, 6 percent more than a year earlier.

The three largest equity deals in the world so far this year were all in Asia, including the Japanese government's $7.7 billion (5.0 billion pounds) stake sale in Japan Tobacco Inc , Minsheng Banking Corp's $3.2 billion (2.1 billion pounds) convertible bond and the $3.1 billion (2.0 billion pounds) sale of new shares by China Petroleum & Chemical Corp (Sinopec) .

The $1.3 billion (858.4 million pounds) IPO of Mapletree Greater China Commercial Trust underscored a trend expected to continue for the remainder of the year, with yield-hungry investors looking to boost returns with global interest rates seen low for the foreseeable future.

"Interest rates remain very low so investors continue to search for yield," said Jonathan Penkin, head of equity capital markets for Asia ex-Japan at Goldman Sachs in Hong Kong. "High quality assets with a yield element are all near or at the top of their historical trading ranges."

Still, IPO activity sank 56 percent from last year to $3.3 billion (2.1 billion pounds), making it the slowest start of the year in the region since 2009. Despite the downturn early into 2013, bankers expect activity to pick up in coming months, with listings from motor sport racing company Formula One and Alibaba Group, and multibillion-dollar offerings from China Galaxy Securities, Sinopec Engineering and several medium-sized Chinese banks.

"Alibaba will redefine the year," said an equity capital markets banker at a global investment bank, who was not authorized to speak publicly on the matter.

(Reporting By Olivia Oran in New York, Kylie MacLellan in London and Elzio Barreto in Hong Kong; Editing by Soyoung Kim and Steve Orlofsky)

Source: http://news.yahoo.com/global-ipos-rise-stock-market-rebound-private-equity-090201898--sector.html

chris brown and rihanna nightline brady quinn brady quinn bloom box obama sweet home chicago accenture match play

Picking apart photosynthesis: New insights could lead to better catalysts for water splitting

Mar. 28, 2013 ? Chemists at the California Institute of Technology (Caltech) and the Lawrence Berkeley National Laboratory believe they can now explain one of the remaining mysteries of photosynthesis, the chemical process by which plants convert sunlight into usable energy and generate the oxygen that we breathe. The finding suggests a new way of approaching the design of catalysts that drive the water-splitting reactions of artificial photosynthesis.

"If we want to make systems that can do artificial photosynthesis, it's important that we understand how the system found in nature functions," says Theodor Agapie, an assistant professor of chemistry at Caltech and principal investigator on a paper in the journal Nature Chemistry that describes the new results.

One of the key pieces of biological machinery that enables photosynthesis is a conglomeration of proteins and pigments known as photosystem II. Within that system lies a small cluster of atoms, called the oxygen-evolving complex, where water molecules are split and molecular oxygen is made. Although this oxygen-producing process has been studied extensively, the role that various parts of the cluster play has remained unclear.

The oxygen-evolving complex performs a reaction that requires the transfer of electrons, making it an example of what is known as a redox, or oxidation-reduction, reaction. The cluster can be described as a "mixed-metal cluster" because in addition to oxygen, it includes two types of metals -- one that is redox active, or capable of participating in the transfer of electrons (in this case, manganese), and one that is redox inactive (calcium).

"Since calcium is redox inactive, people have long wondered what role it might play in this cluster," Agapie says.

It has been difficult to solve that mystery in large part because the oxygen-evolving complex is just a cog in the much larger machine that is photosystem II; it is hard to study the smaller piece because there is so much going on with the whole. To get around this, Agapie's graduate student Emily Tsui prepared a series of compounds that are structurally related to the oxygen-evolving complex. She built upon an organic scaffold in a stepwise fashion, first adding three manganese centers and then attaching a fourth metal. By varying that fourth metal to be calcium and then different redox-inactive metals, such as strontium, sodium, yttrium, and zinc, Tsui was able to compare the effects of the metals on the chemical properties of the compound.

"When making mixed-metal clusters, researchers usually mix simple chemical precursors and hope the metals will self-assemble in desired structures," Tsui says. "That makes it hard to control the product. By preparing these clusters in a much more methodical way, we've been able to get just the right structures."

It turns out that the redox-inactive metals affect the way electrons are transferred in such systems. To make molecular oxygen, the manganese atoms must activate the oxygen atoms connected to the metals in the complex. In order to do that, the manganese atoms must first transfer away several electrons. Redox-inactive metals that tug more strongly on the electrons of the oxygen atoms make it more difficult for manganese to do this. But calcium does not draw electrons strongly toward itself. Therefore, it allows the manganese atoms to transfer away electrons and activate the oxygen atoms that go on to make molecular oxygen.

A number of the catalysts that are currently being developed to drive artificial photosynthesis are mixed-metal oxide catalysts. It has again been unclear what role the redox-inactive metals in these mixed catalysts play. The new findings suggest that the redox-inactive metals affect the way the electrons are transferred. "If you pick the right redox-inactive metal, you can tune the reduction potential to bring the reaction to the range where it is favorable," Agapie says. "That means we now have a more rational way of thinking about how to design these sorts of catalysts because we know how much the redox-inactive metal affects the redox chemistry."

The paper in Nature Chemistry is titled "Redox-inactive metals modulate the reduction potential in heterometallic manganese-oxido clusters." Along with Agapie and Tsui, Rosalie Tran and Junko Yano of the Lawrence Berkeley National Laboratory are also coauthors. The work was supported by the Searle Scholars Program, an NSF CAREER award, and the NSF Graduate Research Fellowship Program. X-ray spectroscopy work was supported by the NIH and the DOE Office of Basic Energy Sciences. Synchrotron facilities were provided by the Stanford Synchrotron Radiation Lightsource, operated by the DOE Office of Biological and Environmental Research.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by California Institute of Technology. The original article was written by Kimm Fesenmaier.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Emily Y. Tsui, Rosalie Tran, Junko Yano, Theodor Agapie. Redox-inactive metals modulate the reduction potential in heterometallic manganese?oxido clusters. Nature Chemistry, 2013; 5 (4): 293 DOI: 10.1038/nchem.1578

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/zABlV4-Gj0A/130329125305.htm

packers Dancing With The Stars All Stars Joseph Gordon-Levitt space shuttle Torrey Smith Brother fiona apple awkward

windows - How to upgrade sharepoint foundation 2010 to use SQL ...

We are developing asp.net application which uses SharePoint Foundation 2010 to store and retrieve documents. We have installed 'Standalone' SharePoint Foundation 2010 and used SQL Server 2008 R2 (Standard Edition) as a database for SharePoint Foundation 2010. This is wrong because we need to install SharePoint Foundation 2010 by using 'Server Farm' to use SQL Server 2008 R2 (Standard Edition) as a database. Now we want to know what should we need to do with existing installation to install SharePoint Foundation 2010 (Server Farm) that uses SQL Server 2008 R2 (Standard Edition) as a database. When we click on setup.exe of SharePoint Foundation 2010, it gives options - Repair and Remove. Should we need to remove SharePoint from this option and again install it in Server Farm type or we need to uninstall everying and install it again?

Source: http://stackoverflow.com/questions/15683964/how-to-upgrade-sharepoint-foundation-2010-to-use-sql-server-2008-r2-standard-ed

pee wee herman ketamine ground hogs day 2012 goundhog day punxsutawney egypt soccer riot facebook ipo

Biological transistor enables computing within living cells

Mar. 28, 2013 ? When Charles Babbage prototyped the first computing machine in the 19th century, he imagined using mechanical gears and latches to control information. ENIAC, the first modern computer developed in the 1940s, used vacuum tubes and electricity. Today, computers use transistors made from highly engineered semiconducting materials to carry out their logical operations.

And now a team of Stanford University bioengineers has taken computing beyond mechanics and electronics into the living realm of biology. In a paper to be published March 28 in Science, the team details a biological transistor made from genetic material -- DNA and RNA -- in place of gears or electrons. The team calls its biological transistor the "transcriptor."

"Transcriptors are the key component behind amplifying genetic logic -- akin to the transistor and electronics," said Jerome Bonnet, PhD, a postdoctoral scholar in bioengineering and the paper's lead author.

The creation of the transcriptor allows engineers to compute inside living cells to record, for instance, when cells have been exposed to certain external stimuli or environmental factors, or even to turn on and off cell reproduction as needed.

"Biological computers can be used to study and reprogram living systems, monitor environments and improve cellular therapeutics," said Drew Endy, PhD, assistant professor of bioengineering and the paper's senior author.

The biological computer

In electronics, a transistor controls the flow of electrons along a circuit. Similarly, in biologics, a transcriptor controls the flow of a specific protein, RNA polymerase, as it travels along a strand of DNA.

"We have repurposed a group of natural proteins, called integrases, to realize digital control over the flow of RNA polymerase along DNA, which in turn allowed us to engineer amplifying genetic logic," said Endy.

Using transcriptors, the team has created what are known in electrical engineering as logic gates that can derive true-false answers to virtually any biochemical question that might be posed within a cell.

They refer to their transcriptor-based logic gates as "Boolean Integrase Logic," or "BIL gates" for short.

Transcriptor-based gates alone do not constitute a computer, but they are the third and final component of a biological computer that could operate within individual living cells.

Despite their outward differences, all modern computers, from ENIAC to Apple, share three basic functions: storing, transmitting and performing logical operations on information.

Last year, Endy and his team made news in delivering the other two core components of a fully functional genetic computer. The first was a type of rewritable digital data storage within DNA. They also developed a mechanism for transmitting genetic information from cell to cell, a sort of biological Internet.

It all adds up to creating a computer inside a living cell.

Boole's gold

Digital logic is often referred to as "Boolean logic," after George Boole, the mathematician who proposed the system in 1854. Today, Boolean logic typically takes the form of 1s and 0s within a computer. Answer true, gate open; answer false, gate closed. Open. Closed. On. Off. 1. 0. It's that basic. But it turns out that with just these simple tools and ways of thinking you can accomplish quite a lot.

"AND" and "OR" are just two of the most basic Boolean logic gates. An "AND" gate, for instance, is "true" when both of its inputs are true -- when "a" and "b" are true. An "OR" gate, on the other hand, is true when either or both of its inputs are true.

In a biological setting, the possibilities for logic are as limitless as in electronics, Bonnet explained. "You could test whether a given cell had been exposed to any number of external stimuli -- the presence of glucose and caffeine, for instance. BIL gates would allow you to make that determination and to store that information so you could easily identify those which had been exposed and which had not," he said.

By the same token, you could tell the cell to start or stop reproducing if certain factors were present. And, by coupling BIL gates with the team's biological Internet, it is possible to communicate genetic information from cell to cell to orchestrate the behavior of a group of cells.

"The potential applications are limited only by the imagination of the researcher," said co-author Monica Ortiz, a PhD candidate in bioengineering who demonstrated autonomous cell-to-cell communication of DNA encoding various BIL gates.

Building a transcriptor

To create transcriptors and logic gates, the team used carefully calibrated combinations of enzymes -- the integrases mentioned earlier -- that control the flow of RNA polymerase along strands of DNA. If this were electronics, DNA is the wire and RNA polymerase is the electron.

"The choice of enzymes is important," Bonnet said. "We have been careful to select enzymes that function in bacteria, fungi, plants and animals, so that bio-computers can be engineered within a variety of organisms."

On the technical side, the transcriptor achieves a key similarity between the biological transistor and its semiconducting cousin: signal amplification.

With transcriptors, a very small change in the expression of an integrase can create a very large change in the expression of any two other genes.

To understand the importance of amplification, consider that the transistor was first conceived as a way to replace expensive, inefficient and unreliable vacuum tubes in the amplification of telephone signals for transcontinental phone calls. Electrical signals traveling along wires get weaker the farther they travel, but if you put an amplifier every so often along the way, you can relay the signal across a great distance. The same would hold in biological systems as signals get transmitted among a group of cells.

"It is a concept similar to transistor radios," said Pakpoom Subsoontorn, a PhD candidate in bioengineering and co-author of the study who developed theoretical models to predict the behavior of BIL gates. "Relatively weak radio waves traveling through the air can get amplified into sound."

Public-domain biotechnology

To bring the age of the biological computer to a much speedier reality, Endy and his team have contributed all of BIL gates to the public domain so that others can immediately harness and improve upon the tools.

"Most of biotechnology has not yet been imagined, let alone made true. By freely sharing important basic tools everyone can work better together," Bonnet said.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Stanford University Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Jerome Bonnet, Peter Yin, Monica E. Ortiz, Pakpoom Subsoontorn, and Drew Endy. Amplifying Genetic Logic Gates. Science, 28 March 2013 DOI: 10.1126/science.1232758

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/technology/~3/ED1fLVQ-WsM/130328142400.htm

broncos lehigh walking dead season finale matt flynn denver news frozen planet creighton

Actress Ashley Judd won't run for US Senate

FRANKFORT, Ky. (AP) ? Actress Ashley Judd announced Wednesday she won't run for U.S. Senate in Kentucky against Republican Leader Mitch McConnell, saying she had given serious thought to a campaign but decided her responsibilities and energy need to be focused on her family.

The former Kentucky resident tweeted her decision.

"Regretfully, I am currently unable to consider a campaign for the Senate. I have spoken to so many Kentuckians over these last few months who expressed their desire for a fighter for the people & new leader," Judd wrote.

"While that won't be me at this time, I will continue to work as hard as I can to ensure the needs of Kentucky families are met by returning this Senate seat to whom it rightfully belongs: the people & their needs, dreams, and great potential. Thanks for even considering me as that person & know how much I love our Commonwealth. Thank you!"

Her publicist Cara Tripicchio confirmed Judd's decision.

The 44-year-old Judd had hinted last week that she was nearing a decision about the race.

Now living in suburban Nashville, Tenn., Judd has said little publicly about her intentions. However, she has been meeting with several Democratic leaders, including Gov. Steve Beshear, to discuss a possible run.

Defeating McConnell would be the Democrats' biggest prize of the 2014 election. His seat is one of 14 that Republicans are defending while Democrats try to hold onto 21, hoping to retain or add to their 55-45 edge.

The star of such films as "Double Jeopardy" and "Kiss the Girls" is known for her liberal political views and she would have been running in a largely conservative state where Republicans hold both Senate seats and five of the six seats in the U.S. House.

Former State Treasurer Jonathan Miller, a Judd supporter, said she would have been a strong candidate.

"As a Kentuckian and someone who was really enthusiastic about her as a candidate, this wasn't the news I was hoping for," Miller said. "But as her friend, from the first time we talked about the race last summer, I was very candid about the grueling nature of politics. It's become a very unpleasant business and running against Mitch McConnell would be an extraordinarily difficult and grueling experience."

McConnell, who spent some $20 million on his last election and who has already raised $10 million for the next one, had already been taunting would-be Democratic challengers in a comical online video intended to raise second thoughts about taking on a politician known as brawler. The video plays on the fact that Judd lives in Tennessee.

Republican-leaning group American Crossroads in its own online video also plays on the Tennessee angle and ties her closely to President Barack Obama, who is unpopular in Kentucky.

University of Louisville political scientist Laurie Rhodebeck said Judd certainly wasn't frightened out of the race.

"She doesn't strike me as a shrinking violet," Rhodebeck said. "I think the real issue would be how much disruption she wanted in her life. This was the kind of thing that she would have to throw herself into 100 percent in order to make it worthwhile."

Judd and three-time Indianapolis 500 winner Dario Franchitti separated early this year after marrying in his native Scotland in 2001.

Judd's decision not to enter the race leaves the Democratic Party in search of a candidate. Many of Kentucky's top Democrats, including Beshear, have said they won't run. However, a rising star within the party, Secretary of State Alison Lundergan Grimes, hasn't ruled the race out. Grimes declined comment Wednesday evening through her spokeswoman, Lynn Sowards Zellen.

___

Associated Press writer Janet Cappiello contributed to this report.

Source: http://news.yahoo.com/actress-ashley-judd-wont-run-us-senate-213309573--politics.html

kendrick perkins steve jones emily maynard kola boof burmese python ferris bueller god bless america